Cardiovascular – Gerfa Labs

Cardiovascular

Cildoz-CT Tab

Brand Name: Cildoz-CT
Generic Name: Cilnidipine + Chlorthalidone
Dosage Form: Oral Tablet
Composition of Cildoz-CT: Cilnidipine: 10 mg (Calcium Channel Blocker) and Chlorthalidone: 12.5 mg (Thiazide-like Diuretic)

Mechanism of Action:

Cilnidipine in Cildoz-CT is a dual-action calcium channel blocker. It inhibits the influx of calcium ions into smooth muscle cells via voltage-gated L-type calcium channels, which leads to vasodilation and a reduction in blood pressure. Specifically:

- L-type calcium channels in the vascular smooth muscle are blocked, causing arterial relaxation and reducing peripheral vascular resistance, which lowers blood pressure.
- In addition to blocking the L-type channels, cilnidipine also inhibits N-type calcium channels in the sympathetic nervous system. This reduces the release of norepinephrine, thereby lowering sympathetic tone and contributing to a further decrease in blood pressure.

This dual action (both vascular and sympathetic inhibition) differentiates cilnidipine from other calcium channel blockers, which only act on L-type channels and thus do not have an additional effect on the sympathetic nervous system.

Chlorthalidone – Class: Thiazide-like Diuretic

Chlorthalidone in Cildoz-CT works primarily by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron in the kidneys. This leads to increased excretion of sodium and chloride ions in the urine.

Indications:

This combination is primarily used in the management of hypertension (high blood pressure) to lower blood pressure and reduce the risk of cardiovascular events.

Packaging:

Each Alu-Alu strip of Cildoz-CT contains 10 tablets.

Gertel-40 Tab

Brand Name: Gertel 40
Generic Name: Telmisartan
Dosage Form: Oral Tablet
Composition of Cildoz-CT: Telmisartan 40 mg per tablet

Mechanism of Action:

Gertel 40 blocks the angiotensin II type 1 (AT1) receptor, inhibiting the vasoconstrictor and aldosterone-secreting actions of angiotensin II, resulting in vasodilation, lowered blood pressure, and kidney protection. It is used to treat hypertension, heart failure, and chronic kidney disease while offering a long-acting effect, allowing once-daily dosing.

Indications

Hypertension: Gertel 40 is used to treat high blood pressure (hypertension). It can be used alone or in combination with other antihypertensive agents.
Cardiovascular Risk Reduction: It is also used for reducing the risk of cardiovascular events in patients who are at high risk for heart disease, such as those with a history of stroke, heart attack, or diabetes.
Heart Failure: It may be prescribed for managing heart failure to help the heart pump more efficiently.

Packaging:

Each Alu-Alu strip of Gertel-40 contains 10 tablets.

Gertel-AM Tab

Brand Name: Gertel-AM
Generic Name: Telmisartan + Amlodipine Combination
Dosage Form: Oral Tablet
Composition of Cildoz-CT: Telmisartan: 40 mg + Amlodipine: 5 mg

Mechanism of Action of Telmisartan + Amlodipine:

Telmisartan blocks the angiotensin II receptor to cause vasodilation and reduce aldosterone secretion, lowering blood pressure.
Amlodipine blocks calcium channels, causing vasodilation and reducing vascular resistance and cardiac workload.
Together, these drugs provide synergistic blood pressure reduction, improving outcomes in patients with hypertension and other cardiovascular conditions.

Indications

Hypertension (High Blood Pressure): This combination is used to treat hypertension in patients who are not adequately controlled with either medication alone or as initial therapy when blood pressure is not adequately controlled by one agent.
Hypertensive Patients with Comorbid Conditions: It may also be prescribed to patients with additional cardiovascular risk factors, such as diabetes or a history of heart disease.

Packaging:

Each Alu-Alu strip of Gertel-AM contains 10 tablets.

Rozva 10 Tab

Brand Name: Rozva-10
Generic Name: Rosuvastatin
Dosage Forms: Oral Tablet
Strength of Rozva-10: Rosuvastatin 10 mg Tab

Mechanism of Action (MOA): Rozva-10

Mechanism of Action: Rosuvastatin is an HMG-CoA reductase inhibitor (statin) that reduces cholesterol synthesis in the liver by inhibiting the enzyme HMG-CoA reductase. This leads to a decrease in LDL-C levels and an increase in HDL-C levels, thereby lowering overall cardiovascular risk.

Indications of Rozva-10:

Rosuvastatin is prescribed for the following conditions:

Hyperlipidemia: To reduce elevated total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides in adults and children ≥10 years of age.
Primary Hypercholesterolemia: For the treatment of primary hypercholesterolemia (type IIa) and mixed dyslipidemia (type IIb).
Prevention of Cardiovascular Events: To reduce the risk of cardiovascular events, including heart attacks, strokes, and the need for revascularization procedures in patients with a history of cardiovascular disease or at risk of developing cardiovascular disease.
Familial Hypercholesterolemia: For the treatment of adults and children ≥10 years old with heterozygous familial hypercholesterolemia.
Hypertriglyceridemia: To reduce elevated triglyceride levels.

Packaging:

Each Alu-Alu strip of Rozva-10 contains 10 tablets.

Rozva 20 Tab

Brand Name: Rozva-20
Generic Name: Rosuvastatin
Dosage Forms: Oral Tablet
Strength of Rozva-10: Rosuvastatin 20 mg Tab

Mechanism of Action (MOA): Rozva-20

Mechanism of Action: Rosuvastatin is an HMG-CoA reductase inhibitor (statin) that reduces cholesterol synthesis in the liver by inhibiting the enzyme HMG-CoA reductase. This leads to a decrease in LDL-C levels and an increase in HDL-C levels, thereby lowering overall cardiovascular risk.

Indications of Rozva-20:

Rosuvastatin is prescribed for the following conditions:

Hyperlipidemia: To reduce elevated total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides in adults and children ≥10 years of age.
Primary Hypercholesterolemia: For the treatment of primary hypercholesterolemia (type IIa) and mixed dyslipidemia (type IIb).
Prevention of Cardiovascular Events: To reduce the risk of cardiovascular events, including heart attacks, strokes, and the need for revascularization procedures in patients with a history of cardiovascular disease or at risk of developing cardiovascular disease.
Familial Hypercholesterolemia: For the treatment of adults and children ≥10 years old with heterozygous familial hypercholesterolemia.
Hypertriglyceridemia: To reduce elevated triglyceride levels.

Packaging:

Each Alu-Alu strip of Rozva-20 contains 10 tablets.